张云，研究员，博士生导师。国家“百千万人才工程”入选者、国家有突出贡献中青年专家，享受国务院特殊津贴专家。获第九届侨界贡献奖一等奖，当选中国侨联第十届委员会委员，中国稀土学会稀土生物医学专业委员会秘书长，中国侨联特聘专家，厦门市欧美同学会副会长。主要从事稀土光电功能材料、稀土纳米材料在生物医学分子诊断、多模态影像与治疗中的研究及应用转化，在稀土纳米荧光探针发光调控及表面生物偶联方面取得系列成果。先后承担了国防科技创新特区项目、国家自然科学基金国际合作项目、中科院科技服务网络计划（STS）项目、福建省战略性新兴产业重点专项等，在Science Advances、ACS Nano, Progress in Materials Science, Cancer Research, Advanced Science, Advanced Functional Materials, Analytical Chemistry等期刊上发表多篇论文。授权发明专利和实用新型专利25项。其主持开发的新冠病毒抗体检测、危重疾病标志物检测等稀土探针快速诊断试剂盒已获得国家医疗器械注册证19项，欧盟CE认证30项。被授予“福建省抗击新冠肺炎疫情先进个人”。相关成果入选了中科院2020年第1、3季度科技创新亮点成果，获2021年度中国稀土科学技术奖一等奖，福建省科学技术进步奖、入选2021年度“中国稀土十大科技新闻”和2021年度“科创中国”先导技术榜单。

 
    研究领域：

    1. 稀土多功能纳米材料的设计与合成

 
    2. 稀土生物医学精准诊疗应用研究 

    3. 稀土生物纳米材料在分子检测技术中的开发、应用和产品转化   

    4. 表面增强拉曼散射在生物医学领域中的应用

 
    近期论文论著：

    1、Na Chen†, Jing Xi†, Na Du†, Ruichen Shen, Rui Zhao, Wei He, Tianhuang Peng, Yanbing Yang, Yun Zhang*, Lilei Yu*, Weihong Tan*, Quan Yuan1, *Framework nucleic acid strategy enables closer microbial contact for programming short-range interaction，Sci. Adv. 10, eadr4399 (2024)

    2、Junpeng Shi, Xia Sun, Liang Song, Maochun Hong, Quan Yuan *,Yun Zhang,*Inorganic persistent luminescence materials: Emerging optical theranostic agents，Progress in Materials Science, 142 (2024) 101246

    3、Xiaofang Luo, Junpeng Shi,* Ruoping Wang, Longlong Cao, Yan Gao, Jinyuan Wang, Maochun Hong, Xia Sun,* and Yun Zhang*, Near-Infrared Persistent Luminescence Nanoprobe for Early Detection of Atherosclerotic Plaque, ACS Nano, 2024, 18, 6500−6512

    4、Yan Gao, Junpeng Shi,* Chen Wu, Longlong Cao, Lin Liu, Jinyuan Wang, Xiaofang Luo, Xiao Zhang,*and Yun Zhang*,Functional Green-Emitting Mn2+-doped Zinc Germanate Persistent Luminescent Nanoparticles for Dual-Mode Immunochromatographic Detection, Anal. Chem. 2024, 96, 5694−5701

    5、Lin Liu, Junpeng Shi,* Jinyuan Wang, Linping He, Yan Gao, Peng Lin, Yutong Han, Ping’an Ma, Jun Lin,* and Yun Zhang*，Biodegradable Persistent Luminescence Nanoparticles as Pyroptosis Inducer for High-Efficiency Tumor Immunotherapy，Adv. Sci. 2024, 2406340

    6、Ruoping Wang, Junpeng Shi,* Qian Zhang, Qiang Peng, Xia Sun, Liang Song,and Yun Zhang*，Dual-Triggered Near-Infrared Persistent Luminescence Nanoprobe for Autofluorescence-Free Imaging-Guided Precise Therapy of Rheumatoid Arthritis，Adv. Sci. 2023, 10, 2205320

    7、Peng Lin, Junpeng Shi,* Ye Lin, Qian Zhang, Kexin Yu, Lin Liu, Liang Song, Yile Kang, Maochun Hong,* and Yun Zhang*，Near-Infrared Persistent Luminescence Nanoprobe for Ultrasensitive Image-Guided Tumor Resection，Adv. Sci. 2023, 2207486

    8、Yuan-Yuan Zhu, Liang Song, Yong-Qu Zhang, Wan-Ling Liu, Wei-Ling Chen,Wen-Liang Gao, Li-Xin Zhang, Jia-Zheng Wang, Zi-He Ming, Yun Zhang*, and Guo-Jun Zhang*，Development of a Rare Earth Nanoprobe Enables In Vivo Real-Time Detection of Sentinel Lymph Node Metastasis of Breast Cancer Using NIR-IIb Imaging，Cancer Res; 83(20) October 15, 2023

    9、Qiang Peng, Ruoping Wang, Qian Zhang, Honghan Yuan, Xiaofang Luo, Wanzhen Lin, Junpeng Shi,Liang Song,* Maochun Hong, and Yun Zhang*，pH-Responsive Targeted Epigallocatechin Gallate-Delivery Nanosystem for in Vivo Persistent Luminescence Imaging and Synergistic Therapy of Bacterial Infection，ACS Materials Lett. 2023, 5, 3161−3170

    10、Lin Liu, Junpeng Shi, Xia Sun, Yongqu Zhang, Jingwang Qin, Shanshan Peng, Jixuan Xu, Liang Song, Yun Zhang*. Thermo-responsive hydrogel-supported antibacterial material with persistent photocatalytic activity for continuous sterilization and wound healing. Compos Part B-Eng, 229, 2022, 109459.

    11、Peng Lin, Junpeng Shi*, Liyan Ming, Yangyang Sheng, Liang Song Maochun Hong*, Yun Zhang*. An intelligent persistent luminescence nanoplatform with high-efficiency O2 utilization for continuous hypoxic tumors treatment, Chem Eng J, 442 (2022) 135638.

    12、Ruoping Wang, Junpeng Shi,* Liang Song, Shenghui Zheng, Xiaolong Liu, Maochun Hong, and Yun Zhang.* Sustained Antitumor Immunity Based on Persistent Luminescence Nanoparticles for Cancer Immunotherapy. Adv Funct Mater, 2021, 31, 2106884.

    13、Liyan Ming, Liang Song*, Jixuan Xu, Ruoping Wang, Junpeng Shi, Min Chen, and Yun Zhang*.  Smart Manganese Dioxide-Based Lanthanide Nanoprobes for Triple-Negative Breast Cancer Precise Gene Synergistic Chemodynamic Therapy. ACS Appl Mater Inter， 2021, 13, 35444−35455.

    14、Yu Han, Si-Rong Wu, Xiang-Dong Tian*, Yun Zhang*. Optimizing the SERS Performance of 3D Substrates through Tunable 3D Plasmonic Coupling toward Label-Free Liver Cancer Cell Classification. ACS Appl Mater Inter，2020, 12(26): 28965-28974.

    15、Junpeng Shi#, Xia Sun#, Shenghui Zheng, Liang Song, Fangrong Zhang, Tobias Madl, Yun Zhang*, Hongwu Zhang*, Maochun Hong. Tin-Doped Near-Infrared Persistent Luminescence Nanoparticles with Considerable Improvement of Biological Window Activation for Deep Tumor Photodynamic Therapy. ACS Appl. Bio Mater, 2020, 3, 5995-6004.

   授权专利：

    1.张云，王选东，卢灿忠，刘小龙，田向东。用于肿瘤MRI/CT成像和光热治疗的多功能纳米探针及应用。发明专利，专利号：ZL201510081016.4

    2.张云，周丹，安汉祥，汤玮玮。PCDH18基于在制备结直肠癌诊断试剂盒中的应用及试剂盒。发明专利，专利号：ZL201610300848.5

    3.田向东，张云，李剑锋。银纳米棒的合成以及基于其制备表面增强拉曼光谱基底。发明专利，专利号：ZL201710218909.8

    4.张云，宋良，明丽艳，张肖，稀土掺杂纳米探针及制备及新冠状病毒检测探针。发明专利，专利号：ZL202010192045.9

    5.张云，张肖，刘宁，宋良，一种COVID-19抗原检测卡、其制备方法和应用。发明专利，专利号： ZL202110255299.8

    6.张云，史俊朋，钟红芸，柳林，一种紫外和近红外双发射的长余辉材料及其制备方法。发明专利，专利号：ZL202210966834.2

    7.张云、史俊朋、彭珊珊，一种可自激活的紫外长余辉发光材料及其制备方法。发明专利，专利号：ZL202111550866.6

    8.张云，张肖，宋良，PTH稀土检测试剂盒及检测卡及其微球及制备与检测方法。发明专利，专利号：ZL202010191502.2

    9.张云，张肖，宋良，心肺五联检测试剂盒及其稀土纳米荧光检测卡和检测方法。发明专利，专利号：ZL202010191498.X

    10.史俊朋，张云，王若平，稀土离子共掺杂近红外长余辉纳米材料、其制备方法和应用，ZL202110953858.X，授权发明专利

    11.张云，张肖，宋良，PTH稀土检测试剂盒及检测卡及其微球及制备与检测方法，ZL202010191502.2，授权发明专利

    12.张云，史俊朋，钟红芸，柳林，一种紫外和近红外双发射的长余辉材料及其制备方法，ZL202210966834.2，授权发明专利

    13.张云、史俊朋、彭珊珊，一种可自激活的紫外长余辉发光材料及其制备方法，ZL202111550866.6，授权发明专利

    14.张云，史俊朋，郑含润，一种Mn2+掺杂红光长余辉发光材料及其制备方法， ZL202111568267.7，授权发明专利

    15.张云，史俊朋，钟红芸，柳林，一种离子共掺杂的紫外长余辉发光材料、制备方法及其应用 ZL20211412106.91，授权发明专利